Multi-lamellar emulsion
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Multi-Lamellar Emulsion (MLE) is an oil-in-water (O/W) emulsion showing multi-lamellar structure and an original technology developed by NeoPharm in South Korea.
MLE is made with NeoPharm's proprietary pseudo-ceramide, PC-9S. The Lamellar structure, also observed in the stratum corneum, is defined as a thin plate or membrane of skin lipids. MLE shows multiple layers of this lamellar structure, and as a moisturizer, MLE offers long-lasting skin moisturizing effects through reinforcing the skin's natural barrier function.
Under cross-polarized microscopy, skin lipids and MLE show a similar cross-like structure, termed the Maltese cross structure, and under electron microscopy, lamellar structures are observed. The stratum corneum, as the outermost layer of skin, is responsible for the various barrier functions of the skin and protects our body from externally harmful things.[citation needed]
Stratum corneum lipids are elaborately organized into lamellar structure, which plays the most important role for skin's barrier functions. Unlike conventional moisturizers made with humectants or emollients, MLE can restore and improve the barrier function of skin with its distinctive structural similarity to the native human skin's lamellar structure. Restoring the skin barrier function can improve skin hydration and protect skin from external irritants.[citation needed]
The efficacy of MLE on the skin barrier was proven by several clinical studies performed in independent university, hospitals and reported in peer-reviewed academic journals, including the Journal of Investigative Dermatology, one of the most renowned journals in the field of dermatology. Along with its therapeutic benefits, MLE also has non-sticky textures, allowing quick absorption after application.
As an O/W emulsion, MLE can also be used as a vehicle (carrier) for topical drugs. The multiple layers of MLE offer stabilization of active pharmaceutical ingredients (API) and efficient penetration of API into the skin.[citation needed]
( * under electron microscopy )
B. Lamellar structure of MLE
( * under electron microscopy )
C. Maltese cross of skin lipid
( * under cross-polarized microscopy )
D. Maltese cross of MLE
( * cross-polarized microscopy )